研究業績（個人：教員：兒玉哲也）

3 研究業績

原著論文

  1. Morihiro K, Kodama T, Kentefu, Moai Y, Veedu RN, Obika S.
    Selenomethylene locked nucleic acid enables reversible hybridization in response to redox changes.
    Angew Chem Int Ed Engl. 2013 May 3;52(19):5074-5078. doi: 10.1002/anie.201300555.（査読有）
  2. Yahara A, Shrestha AR, Yamamoto T, Hari Y, Osawa T, Yamaguchi M, Nishida M, Kodama T, Obika S.
    Amido-bridged nucleic acids (AmNAs): synthesis, duplex stability, nuclease resistance, and in vitro antisense potency.
    Chembiochem. 2012 Nov 26;13(17):2513-2516. doi: 10.1002/cbic.201200506. （査読有）
  3. Wheeler M, Chardon A, Goubet A, Morihiro K, Tsan SY, Edwards SL, Kodama T, Obika S, Veedu RN.
    Synthesis of selenomethylene-locked nucleic acid (SeLNA)-modified oligonucleotides by polymerases.
    Chem Commun (Camb). 2012 Nov 18;48(89):11020-11022. doi: 10.1039/c2cc36464f.（査読有）
  4. Rahman SM, Baba T, Kodama T, Islam MA, Obika S.
    Hybridizing ability and nuclease resistance profile of backbone modified cationic phosphorothioate oligonucleotides.
    Bioorg Med Chem. 2012 Jul 1;20(13):4098-4102. doi: 10.1016/j.bmc.2012.05.009. （査読有）
  5. Kawada Y, Kodama T, Miyashita K, Imanishi T, Obika S.
    Synthesis and evaluation of novel caged DNA alkylating agents bearing 3,4-epoxypiperidine structure.
    Org Biomol Chem. 2012 Jul 14;10(26):5102-8. doi: 10.1039/c2ob25366f.（査読有）
  6. Kazuto Mori, Tetsuya Kodama, Satoshi Obika.
    Design, synthesis and properties of boat-shaped glucopyranosyl nucleic acid.
    Org. Lett. 2011, 13, 6050–6053. （査読有）
  7. Kosuke Ramon Ito, Tetsuya Kodama, Futaba Makimura, Noritsugu Hosiki, Tomohisa Osaki, Ayako Orita, Takeshi Imanishi, Satoshi Obika.
    Cleavage of oligonucleotides containing a P3’→N5’ phosphoramidite linkage mediated by single-stranded oligonucleotide templates.
    Molecules., 2011, 16, 10695-10708. （査読有）
  8. Kunihiko Morihiro, Tetsuya Kodama, Satoshi Obika.
    Benzylidene acetal-type bridged nucleic acids: changes in properties upon cleavage of the bridge triggered by external stimuli.
    Chem. Eur. J. 2011, 17, 7918—7926. （査読有）
  9. Kwan-Young Jung, Tetsuya Kodama, Marc M. Greenberg.（査読有）
    Repair of the major lesion resulting from C5′-oxidation of DNA.
    Biochemistry 2011, 50, 6273–6279.
  10. Kazuto Mori, Tetsuya Kodama, Takeshi Baba, Satoshi Obika.
    Bridged nucleic acid conjugates at 6’-thiol: synthesis, hybridization properties and nuclease resistances.
    Org. Biomol. Chem. 2011, 9, 5272—5279. （査読有）
  11. Yoshiyuki. Hari, Tetsuya Kodama, Takeshi Imanishi, Satoshi Obika.
    2’-O,4’-C-Methyleneoxymethylene bridged nucleic acid (2’,4’-BNACOC).
    Therapeutic Oligonucleotides: Methods and Protocols, John Goodchild Ed., pp 31—57, Humana Press (2011). （査読有）
  12. Takeshi Baba, Tetsuya Kodama, Kazuto Mori, Takeshi Imanishi, and Satoshi Obika.
    A novel bridged nucleoside bearing a conformationally switchable sugar moiety in response to redox changes. Chem. Commun., 2010, 46, 8058-8060. （査読有）
  13. Kosuke Ramon Ito, Tetsuya Kodama, Masaharu Tomizu, Yoshinori Negoro, Ayako Orita, Tomohisa Osaki, Noritsugu Hosoki, Takaya Tanaka, Takeshi Imanishi, and Satoshi Obika.
    Double-stranded DNA-templated cleavage of oligonucleotides containing a P3’→N5′ linkage triggered by triplex formation: the effects of chemical modifications and remarkable enhancement in reactivity. Nucleic Acids Res., 2010, 38, 7332-7342. （査読有）
  14. Masaru Nishida, Takeshi Baba, Tetsuya Kodama, Aiko Yahara, Takeshi Imanishi, and Satoshi Obika.
    Synthesis, RNA selective hybridization and high nuclease resistance of an oligonucleotide containing novel bridged nucleic acid with cyclic urea structure. Chem. Commun., 2010, 46, 5283-5285. （査読有）
  15. Yuji Kawada, Tetsuya Kodama, Kazuyuki Miyashita, Takeshi Imanishi, and Satoshi Obika.
    Synthesis and evaluation of novel 3,4-epoxypiperidines as efficient DNA alkylating agents. Heterocycles, 2010, 80, 1249-1265. （査読有）
  16. Kunihiko Morihiro, Tetsuya Kodama, Masaru Nishida, Takeshi Imanishi and Satoshi Obika.
    Synthesis of light-responsive bridged nucleic acid and changes in affinity with complementary ssRNA. ChemBioChem, 2009, 10, 1784-1788. （査読有）
  17. Tetsuya Kodama, Chieko Matsuo, Hidetsugu Ori, Tetsuya Miyoshi, Satoshi Obika, Kazuyuki Miyashita, Takeshi Imanishi.
    Design, synthesis, and evaluation of a novel bridged nucleic acid, 2′,5′-BNAON, with S-type sugar conformation fixed by N–O linkage. Tetrahedron, 2009, 65, 2116-2123. （査読有）
  18. Yasunori Mitsuoka, Tetsuya Kodama, Ryo Ohnishi, Yoshiyuki Hari, Takeshi Imanishi and Satoshi Obika.
    A Bridged Nucleic Acid, 2’,4’-BNACOC: Synthesis of Fully Modified Oligonucleotides Bearing Thymine, 5-Methylcytosine, Adenine and Guanine 2’,4’-BNACOC Monomers, and RNA-selective Nucleic Acid Recognition. Nucleic Acids Res., 2009, 37, 1225-1238. （査読有）
  19. 14.    Tetsuya Kodama, Kensaku Sugaya, Takeshi Baba, Takeshi Imanishi and Satoshi Obika.
    Synthesis of a Novel trans-3’,4’-BNA Monomer Bearing a 4,8-Dioxa-5-azabicyclo[5.3.0]decane Skeleton. Heterocycles, 2009, 79, 873-882. （査読有）
  20. Tetsuya Kodama, Kensaku Sugaya, Yasuki Harada, Yasunori Mitsuoka, Takeshi Imanishi and Satoshi Obika.
    Synthesis and Properties of 2’-Deoxy-trans-3’,4’-BNA with S-type Sugar Puckering. Heterocycles, 2009, 77, 1209-1217. （査読有）
  21. Shanta Dhar, Tetsuya Kodama, and Marc M. Greenberg.
    Selective detection and quantification of oxidized abasic lesions in DNA. J. Am. Chem. Soc. 2007, 129, 8702-8703.  （査読有）
  22. Tetsuya Kodama, Akira Matsuda and Satoshi Shuto.
    Synthesis of 1’-fluorouracil nucleosides as potential antimetabolites. Tetrahedron 2006, 62, 10011-10017. （査読有）
  23. Tetsuya Kodama, Satoshi Shuto and Akira Matsuda.
    Synthesis of pyrimidine 1’-fluoronucleosides. Tetrahedron Lett. 2006, 47, 4429-4432. （査読有）
  24. Tetsuya Kodama and Marc M. Greenberg.
    Preparation and analysis of oligonucleotides containing lesions resulting from C5’-oxidation. J.Org. Chem. 2005, 70, 9916-9924. （査読有）
  25. Brian C. Bales, Tetsuya Kodama, Yvonne N. Weledji, Marguerite Pitie, Bernard Meunier and Marc M. Greenberg.
    Mechanistic studies on DNA damage by minor groove binding copper–phenanthroline conjugates. Nucleic Acids Res. 2005, 33, 5371-5379. （査読有）
  26. Yuji Yamamoto, Satoshi Shuto, Yutaka Tamura, Tetsuya Kodama, Shuichi Hoshika, Satoshi Ichikawa, Yoshihito Ueno, Eiko Ohtsuka, Yasuo Komatsu and Akira Matsuda.
    Oligodeoxynucleotides having a loop consisting of 3′-deoxy-4′-C-(2-hydroxyethyl)thymidines form stable hairpins. Biochemistry 2004, 43 8690-8699. （査読有）
  27. Tetsuya Kodama, Satoshi Shuto, Satoshi Ichikawa and Akira Matsuda.
    A highly stereoselective samarium diiodide-promoted aldol reaction with l’-phenylseleno-2′-keto nucleosides. Synthesis of 1’alpha-branched uridine derivatives. J. Org. Chem. 2002, 67 7706-7715. （査読有）
  28. Satoshi Shuto, Makiko Kanazaki, Isamu Sugimoto, Satoshi Ichikawa, Yuki Nagasawa, Yoshihito Ueno, Hiroshi Abe, Noriaki Minakawa, Makoto Sukeda, Tetsuya Kodama, Makoto Nomura and Akira Matsuda.
    Development of New Radical Reactions with a vinylsilyl group and their application to the syntheis of branched chain sugar nucleosides. Recent Advances in Nucleosides: chemistry and chemotherapy 2002, 21-55. （査読有）
  29. Tetsuya Kodama, Satoshi Shuto and Akira Matsuda.
    An efficient method for the preparation of 1’alpha-branched-chain sugar pyrimidine ribonucleosides from uridine: The first conversion of a natural nucleoside into 1′-substituted ribonucleosides. Chem. Eur. J. 2001, 7, 2332-2340. （査読有）
  30. Tetsuya Kodama, Satoshi Shuto, Makoto Nomura and Akira Matsuda.
    Synthesis of a 1′-alpha-phenylselenouridine derivative as a synthetic precursor for various 1′-modified nucleosides, via enolization at the 1′-position of 3′,5′-O-TIPDS-2′-ketouridine. Tetrahedron Lett. 2000, 41, 3643-3646. （査読有）

 

 

総説、解説

 

  1. 兒玉哲也. 外部刺激応答型人工核酸スイッチの設計と合成. Yakugaku Zasshi, 2011, 131, 101-111.
  2. 兒玉哲也, 今西 武, 小比賀 聡. 架橋型人工核酸BNAの開発（４）：外部刺激応答型人工核酸スイッチへの展開. Antisense, 2011, 14, 35-44.

 

 

国際学会要旨等のうち雑誌として引用可能なもの

 

  1. Aiko Yahara, Masaru Nishida, Takeshi Baba, Tetsuya Kodama, Takeshi Imanishi, and Satoshi Obika. Synthesis and properties of a novel 2′,4′-BNA bearing a urea bridged structure. Nucleic Acids Symp Ser., 2009, 53, 11-12.
  2. Takeshi Baba, Tetsuya Kodama, Takeshi Imanishi, and Satoshi Obika. Synthesis and properties of a novel artificial nucleoside that acts as a redox switch. Nucleic Acids Symp Ser., 2009, 53, 107-108.
  3. Kunihiko Morihiro, Tetsuya Kodama, Masaru Nishida, Takeshi Imanishi, and Satoshi Obika. Development of light-responsive BNA toward the spatiotemporal control of gene expression. Nucleic Acids Symp Ser., 2009, 53, 187-188.
  4. Tetsuya Miyoshi, Tetsuya Kodama, Satoshi Obika and Takeshi Imanishi. Design and Chemical Synthesis of a 2′,4′-BNA Probe for 7,8-Dihydro-8-oxoguanine-containing Double Stranded DNA. Nucleic Acids Symp. Ser. 2008, 52, 305-306.
  5. Kensaku Sugaya, Y. Harada, Yasunori Mitsuoka, Tomohisa Osaki, Satoshi Obika, Tetsuya Kodama, Takeshi Imanishi. Synthesis and properties of a 2′-deoxy analogue of trans-3′,4′-BNA with an S-type sugar conformation. Nucleic Acids Symp. Ser., 2007, 51, 155-156.
  6. Masaru Nishida, Tetsuya Kodama, Satoshi Obika, Takeshi Imanishi. Synthesis and chemical properties of a novel 2′,4′-bridged nucleic acid analogue with a seven-membered cyclic carbamate structure. Nucleic Acids Symp. Ser., 2007, 51, 157-158.
  7. Tetsuya Kodama, Chieko Matsuo, Hidetsugu Ori, Satoshi Obika, Kazuyuki Miyashita, Takeshi Imanishi. Synthesis and evaluation of a novel 2′,5′-bridged nucleic acid with sugar conformation fixed to S-type by N-O linkage. Nucleic Acids Symp. Ser., 2007, 51, 159-160.
  8. Tetsuya Kodama, Akira Matsuda and Satoshi Shuto. The first synthesis of 1′-fluoronucleosides. Nucleic Acids Symp. Ser. 2006, 50, 3-4.
  9. Satoshi Shuto, Yutaka Tamura, Yuji Yamamoto, Tetsuya Kodama, Shuichi Hoshika, Satoshi Ichikawa, Yoshihito Ueno, Eiko Ohtsuka, Yasuo Komatsu, and Akira Matsuda. Stable hairpins having a loop consisting of 3′-deoxy-4′-C-(2-hydroxyethyl)thymidines. Nucleic Acids Symp. Ser. 2004, 48, 67-68.
  10. Tetsuya Kodama, Satoshi Shuto, Makoto Nomura and Akira Matsuda. Synthesis and radiacal reaction of 1’-phenylselenonucleosides. Nucleic Acids Symp. Ser. 2000, 44, 109-110.
Updated: 2013/09/10 — 21:11